Essay --

acetaminophen (Tylenol) is an analgesic medication. Its oer dot occurs when some whiz accidently or on purpose takes more than the normal or recommended come in of this medication. Acetaminophen overdose is one of the common poisonings worldwide. If this poisoning occurs, need to call local emergency total (911) or poison control center.Acute acetaminophen overdose is defined as an ingestion of toxic come up of acetaminophen occurring within a period of eight hours or less. In adults acetaminophen toxicity occurs followers ingestion of greater than 7.5-10gms over a period of eight hours or less. Chronic acetaminophen overdose occurs following ingestion of toxic amount over a period greater than eight hours. The mechanism of liver injury is related to the fact that small amounts of acetaminophen ar reborn to a toxic metabolite. The toxic metabolite binds with liver proteins to cause cellular injury. The amount of toxic metabolite produced and the ability of the liver to remov e this metabolite before it binds to liver protein forge the extent of liver injury. PathophysiologyOral acetaminophen is rapidly absorbed from the resist and small intestines. The serum drug concentration peaks 1-2 hours once after ingestion. gush plasma level occurs within 4 hours of post ingestion of over dose of an immediate release preparation. Therapeutic levels are 5-20 g/ml. Acetaminophen primarily metabolized by liver to non toxic, water soluble form that is eliminated in the urine. Overdose leads to formation of hepatotoxic reactive metabolite causes an ensuring cascade of oxidative handicap and mitochondrial dysfunction. This subsequent inflammatory response propagates hepatocellular injury and death. Similar enzymatic response occurs i... ...dressed some recommendations to acetaminophen based medications, are safe daily dose for healthy individuals, patients with chronic renal failure, patients who concurrently drink alcohol and fascinate dose needed to be efficac y. It also imposed package size restrictions.PreventionPeople supposed to take some steps to cancel acetaminophen overdose. Always securely close the acetaminophen containers and use pip-squeak proof bottles. Keep all the medication out of the reach of children. exist the correct dose and amount of drug before administration. Never integrate the both medications if those contain the acetaminophen. Keep all the medications away from the family member who are being showed suicidal ideations and seek medical attention immediately. Patient should non be taken acetaminophen if he has consumed three alcoholic beverages per twenty-four hour period as it leads to hepatotoxicity.